Yes, you can. In the admin area, navigate to Design > Layouts Manager and create a custom layout there. Then, go to Design > Theme Settings > Layouts Builder and select your new custom layout from the dropdown menu. Add the Blocks you want from the left side and then you can assign this layout to a page, category, or product.
You would log in to the admin area and navigate to Design > Theme Settings > Customization and click on the 'Live Customize Design' button.